Glioblastoma Neurovascular Progenitor Orchestrates Tumor Cell Type Diversity.

ABSTRACT: Glioblastoma (GBM) is the deadliest form of primary brain tumor with limited treatment options. Recent studies have profiled GBM tumor heterogeneity, revealing numerous axes of variation that explain the molecular and spatial features of the tumor. Here, we seek to bridge descriptive characterization of GBM cell type heterogeneity with the functional role of individual populations within the tumor. Our lens leverages a gene program-centric meta-atlas of published transcriptomic studies to identify commonalities between diverse tumors and cell types in order to decipher the mechanisms that drive them. This approach led to the discovery of a tumor-derived stem cell population with mixed vascular and neural stem cell features, termed a neurovascular progenitor (NVP). Following in situ

SUBMITTER: Fazzari E 

PROVIDER: S-EPMC11291138 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature