Geometry and Surface Area Optimization in Iron Oxide Nanoparticles for Enhanced Magnetic Properties.

ABSTRACT: Iron oxide nanoparticles (IONPs) are recognized for their potential in biomedical applications due to their distinctive physicochemical properties. This study investigates the synthesis of IONPs with various geometric morphologies-cubic, star-like, truncated icosahedron, and spherical-via thermal decomposition to enhance their utility in magnetic resonance imaging (MRI) and targeted drug delivery. X-ray diffraction analysis verified the Fe₃O₄ phase in all nanoparticles, illustrating the synthesis's efficacy. Particle morphologies were well-defined, with sizes ranging from 10 to 150 nm, as determined by transmission electron microscopy (TEM) and scanning electron microscopy (SEM). Magnetic evaluations using a vibrating sample magnetometer (VSM-PPMs) demonstrated their superparamagnetic behavior, with larger particles exhibiting greater saturation magnetization. Notably, truncated icosahedron and cubic IONPs showed superior transverse relaxation rates, with r₂ values of 56.77 s¹ mM¹ and 42.67 s¹ mM¹, respectively. These results highlight the potential of customizing IONP geometries to optimize their magnetic properties and increase surface area available for functionalization, thereby improving their efficacy for biomedical applications.

SUBMITTER: Lavin Flores A 

PROVIDER: S-EPMC11292628 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature