K_v7 channel opener retigabine reduces self-administration of cocaine but not sucrose in rats.

ABSTRACT: The increasing rates of drug misuse highlight the urgency of identifying improved therapeutics for treatment. Most drug-seeking behaviours that can be modelled in rodents utilize the repeated intravenous self-administration (SA) of drugs. Recent studies examining the mesolimbic pathway suggest that K_v7/KCNQ channels may contribute to the transition from recreational to chronic drug use. However, to date, all such studies used noncontingent, experimenter-delivered drug model systems, and the extent to which this effect generalizes to rats trained to self-administer drugs is not known. Here, we tested the ability of retigabine (ezogabine), a K_v7 channel opener, to regulate instrumental behaviour in male Sprague Dawley rats. We first validated the ability of retigabine t

SUBMITTER: Urena ES 

PROVIDER: S-EPMC11292668 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature