Multi-layered metabolic effects of trehalose on the liver proteome in apoE-knockout mice model of liver steatosis.

ABSTRACT:

Background

Metabolic dysfunction-associated fatty liver disease has been well documented as a key independent risk factor for the development of atherosclerosis. A growing body of evidence suggests that due to its numerous favorable molecular effects, trehalose may exert beneficial effects in counteracting liver steatosis. In our previous study, we described the antiatherosclerotic and antisteatotic properties of trehalose, which we attributed to the induction of autophagy. Considering the pleiotropic activities of trehalose, our present study aimed to extend our preliminary results with the comprehensive examination of proteome-wide changes in the livers of high-fat-fed apoE-/- mice.

Methods

Thus, we applied modern, next-generation proteomic methodology to comprehensively a

SUBMITTER: Pogoda W 

PROVIDER: S-EPMC11294376 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature