Ontology highlight
ABSTRACT:
SUBMITTER: Plumber SA
PROVIDER: S-EPMC11297265 | biostudies-literature | 2024 Aug
REPOSITORIES: biostudies-literature
Plumber Sakina A SA Tate Tiffany T Al-Ahmadie Hikmat H Chen Xiao X Choi Woonyoung W Basar Merve M Lu Chao C Viny Aaron A Batourina Ekatherina E Li Jiaqi J Gretarsson Kristjan K Alija Besmira B Molotkov Andrei A Wiessner Gregory G Lee Byron Hing Lung BHL McKiernan James J McConkey David J DJ Dinney Colin C Czerniak Bogdan B Mendelsohn Cathy Lee CL
Nature communications 20240802 1
Muscle invasive bladder cancers (BCs) can be divided into 2 major subgroups-basal/squamous (BASQ) tumors and luminal tumors. Since Pparg has low or undetectable expression in BASQ tumors, we tested the effects of rosiglitazone, Pparg agonist, in a mouse model of BASQ BC. We find that rosiglitazone reduces proliferation while treatment with rosiglitazone plus trametinib, a MEK inhibitor, induces apoptosis and reduces tumor volume by 91% after 1 month. Rosiglitazone and trametinib also induce a sh ...[more]