Developmental origins of exceptional health and survival: A four-generation family cohort study.

ABSTRACT:

Background

Previous researched has demonstrated potent health and survival advantages across three-generations in longevity-enriched families. However, the survival advantage associated with familial longevity may manifest earlier in life than previously thought.

Methods

We conducted a matched cohort study comparing early health trajectories in third-generation grandchildren (n = 5,637) and fourth-generation great-grandchildren (n = 14,908) of longevity-enriched sibships to demographically matched births (n = 41,090) in Denmark between 1973 and 2018.

Results

Lower risk was observed across a range of adverse early life outcomes in the grandchildren, including infant mortality (Hazard Ratio (HR) = 0.53, 95% CI [0.36, 0.77]), preterm birth (Odds Ratio (OR) = 0.82, [0.72,

SUBMITTER: Keys MT 

PROVIDER: S-EPMC11302717 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature