Revealing an association between HPV and systemic lupus erythematosus: A bidirectional two-sample Mendelian randomization study.

ABSTRACT:

Background

An increasing number of studies have focused on the association between Human papillomavirus (HPV) infection and systemic lupus erythematosus (SLE). However, current evidence is largely based on retrospective studies, which are susceptible to confounding factors and cannot establish causation.

Methods

A bidirectional two-sample Mendelian randomization (MR) design was used to evaluate the causal relationship between HPV and SLE. Mononucleoside polymers (SNPS) with strong evidence for genome-wide association studies (GWAS) were selected from the HPV exposure dataset and used as an instrumental variable (IV) for this study. For the MR Analysis results, the MR-Egger intercept P test, MR-Presso global test, CochranQ test and leave-one test were used for sensitivity ana

SUBMITTER: Pan F 

PROVIDER: S-EPMC11305866 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature