Assessing immune factors in maternal milk and paired infant plasma antibody binding to human rhinoviruses.

ABSTRACT:

Introduction

Before they can produce their own antibodies, newborns are protected from infections by transplacental transfer of maternal IgG antibodies and after birth through breast milk IgA antibodies. Rhinovirus (RV) infections are extremely common in early childhood, and while RV infections often result in only mild upper respiratory illnesses, they can also cause severe lower respiratory illnesses such as bronchiolitis and pneumonia.

Methods

We used high-density peptide arrays to profile infant and maternal antibody reactivity to capsid and full proteome sequences of three human RVs - A16, B52, and C11.

Results

Numerous plasma IgG and breast milk IgA RV epitopes were identified that localized to regions of the RV capsid surface and interior, and also to several n

SUBMITTER: Vera JM 

PROVIDER: S-EPMC11306134 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature