Association between the third trimester maternal serum metabolome and child growth and development through the first year of life.

ABSTRACT: Evidence suggests that maternal metabolome may be associated with child health outcomes. We analyzed the association between the maternal metabolome between 28-35 gestational weeks and child growth and development during the first year. A prospective cohort of 98 mother-child dyads was followed at birth, 1, 6, and 12 months. Maternal serum samples were collected for targeted LC-MS/MS analysis, which measured 132 metabolites. The child's growth and development were assessed at each time-point. Z-scores were calculated based on WHO growth standards, and the domains of development were assessed using the Ages and Stages Questionnaires (ASQ-3). Multiple linear mixed-effects models were performed and confounders were identified using a Diagram Acyclic Graph. The Benjamini-Hochberg correction wa

SUBMITTER: da Silva Rosa Freire S 

PROVIDER: S-EPMC11306240 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature