Lower or higher oxygenation targets in the intensive care unit: an individual patient data meta-analysis.

ABSTRACT:

Purpose

Optimal oxygenation targets for patients with acute hypoxemic respiratory failure in the intensive care unit (ICU) are not clearly defined due to substantial variability in design of previous trials. This study aimed to perform a pre-specified individual patient data meta-analysis of the Handling Oxygenation Targets in the ICU (HOT-ICU) and the Handling Oxygenation Targets in coronavirus disease 2019 (COVID-19) (HOT-COVID) trials to compare targeting a partial pressure of arterial oxygen (PaO₂) of 8-12 kPa in adult ICU patients, assessing both benefits and harms.

Methods

We assessed 90-day all-cause mortality and days alive without life support in 90 days using a generalised mixed model. Heterogeneity of treatment effects (HTE) was evaluated in 14 subgroup

SUBMITTER: Nielsen FM 

PROVIDER: S-EPMC11306534 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature