Significance of PD-L1 and Tumor Microenvironment in Laryngeal Squamous Cell Cancer.

ABSTRACT:

Background

Despite the considerable advancement in the field of medicine over recent decades, laryngeal cancer continues to be a challenge. The field of immune oncology has generated promising immunomodulation therapies and opened up new ways of treatment.

Methods

Our retrospective study included 102 patients diagnosed with laryngeal squamous cell cancer (LSCC). Immunohistochemistry was used to evaluate the expression of PD-L1 and tumor microenvironment cells (CD4, CD8, CD68 and CD163).

Results

PD-L1 expression showed statistically significant positive correlations with all examined tumor microenvironment cells. Patients with high CD68 and CD163 expression intratumorally (p = 0.0005 and p = 0.006, respectively) had statistically significant shorter disea

SUBMITTER: Tudor F 

PROVIDER: S-EPMC11311265 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature