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READv2: advanced and user-friendly detection of biological relatedness in archaeogenomics.


ABSTRACT: The advent of genome-wide ancient DNA analysis has revolutionized our understanding of prehistoric societies. However, studying biological relatedness in these groups requires tailored approaches due to the challenges of analyzing ancient DNA. READv2, an optimized Python3 implementation of the most widely used tool for this purpose, addresses these challenges while surpassing its predecessor in speed and accuracy. For sufficient amounts of data, it can classify up to third-degree relatedness and differentiate between the two types of first-degree relatedness, full siblings and parent-offspring. READv2 enables user-friendly, efficient, and nuanced analysis of biological relatedness, facilitating a deeper understanding of past social structures.

SUBMITTER: Alacamlı E 

PROVIDER: S-EPMC11318251 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature

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READv2: advanced and user-friendly detection of biological relatedness in archaeogenomics.

Alaçamlı Erkin E   Naidoo Thijessen T   Güler Merve N MN   Sağlıcan Ekin E   Aktürk Şevval Ş   Mapelli Igor I   Vural Kıvılcım Başak KB   Somel Mehmet M   Malmström Helena H   Günther Torsten T  

Genome biology 20240812 1


The advent of genome-wide ancient DNA analysis has revolutionized our understanding of prehistoric societies. However, studying biological relatedness in these groups requires tailored approaches due to the challenges of analyzing ancient DNA. READv2, an optimized Python3 implementation of the most widely used tool for this purpose, addresses these challenges while surpassing its predecessor in speed and accuracy. For sufficient amounts of data, it can classify up to third-degree relatedness and  ...[more]

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