Photoelectrochemical Ni-catalyzed cross-coupling of aryl bromides with amine at ultra-low potential.

ABSTRACT: Photoelectrochemical (PEC) cell is an ideal platform for organic transformation because of its green benefits and minimal energy consumption. As an emerging methodology, the reaction types of photoelectrocatalytic organic synthesis (PECOS) are limited to simple oxidation and C-H activation at current stage. Metal catalysis for the construction of C(sp²)-N bonds has not been touched yet in PECOS. We introduce here a PEC method that successfully engages Ni catalysis for the mild production of aniline derivatives. Experimental and computational investigations elucidate that the addition of photoanode-generated amine radical to Ni catalyst avoids the sluggish nucleophilic attack, enabling the reaction to proceed at an ultra-low potential (-0.4 V vs. Ag/AgNO₃) and preventi

SUBMITTER: Wang J 

PROVIDER: S-EPMC11319468 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature