Thianthrene/TfOH-catalyzed electrophilic halogenations using N-halosuccinimides as the halogen source.

ABSTRACT: Organohalides are vital organic building blocks with applications spanning various fields. However, direct halogenation of certain neutral or unreactive substrates by using solely the regular halogenating reagents has proven challenging. Although various halogenation approaches via activating halogenating reagents or substrates have emerged, a catalytic system enabling broad substrate applicability and diverse halogenation types remains relatively underexplored. Inspired by the halogenation of arenes via thianthrenation of arenes, here we report that thianthrene, in combined use with trifluoromethanesulfonic acid (TfOH), could work as an effective catalytic system to activate regular halogenating reagents (NXS). This new protocol could accomplish multiple types of halogenatio

SUBMITTER: Shi H 

PROVIDER: S-EPMC11323329 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature