Locus coeruleus noradrenaline depletion and its differential impact on CO₂-induced panic and hyperventilation in male and female mice.

ABSTRACT: CO₂ exposure has been used to investigate the panicogenic response in patients with panic disorder. These patients are more sensitive to CO₂, and more likely to experience the "false suffocation alarm" which triggers panic attacks. Imbalances in locus coeruleus noradrenergic (LC-NA) neurotransmission are responsible for psychiatric disorders, including panic disorder. These neurons are sensitive to changes in CO₂/pH. Therefore, we investigated if LC-NA neurons are differentially activated after severe hypercapnia in mice. Further, we evaluated the participation of LC-NA neurons in ventilatory and panic-like escape responses induced by 20% CO₂ in male and female wild type mice and two mouse models of altered LC-NA synthesis. Hypercapnia activates

SUBMITTER: Ripamonte GC 

PROVIDER: S-EPMC11323958 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature