Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Rheological properties of porcine organs: measurements and fractional viscoelastic model.

ABSTRACT: The rheological properties of porcine heart, kidney, liver and brain were measured using dynamic oscillatory shear tests over a range of frequencies and shear strains. Frequency sweep tests were performed from 0.1 Hz to a maximum of 9.5 Hz at a shear strain of 0.1%, and strain sweep tests were carried out from 0.01% to 10% at 1 Hz. The effect of pre-compression of samples up to 10% axial strain was considered. The experimental measurements were fit to a Semi-Fractional Kelvin Voight (S-FKV) model. The model was then used to predict the stress relaxation in response to a step strain of 0.1%. The prediction was compared to experimental relaxation data for the porcine organ samples, and the results agreed to within 30%. In conclusion, this study measured the rheological properties of porcine organs and used a fractional viscoelastic model to describe the response in frequency and time domain.

SUBMITTER: Mishra A

PROVIDER: S-EPMC11324450 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature

ACCESS DATA

Json Xml

Publications

Rheological properties of porcine organs: measurements and fractional viscoelastic model.

Mishra Aadarsh A Cleveland Robin O RO

Frontiers in bioengineering and biotechnology 20240801

The rheological properties of porcine heart, kidney, liver and brain were measured using dynamic oscillatory shear tests over a range of frequencies and shear strains. Frequency sweep tests were performed from 0.1 Hz to a maximum of 9.5 Hz at a shear strain of 0.1%, and strain sweep tests were carried out from 0.01% to 10% at 1 Hz. The effect of pre-compression of samples up to 10% axial strain was considered. The experimental measurements were fit to a Semi-Fractional Kelvin Voight (S-FKV) mode ...[more]

PMID: 39148944

Similar Datasets

Rheological characterization of poly-dimethyl siloxane formulations with tunable viscoelastic properties.

Project description:Studies from the past two decades have demonstrated convincingly that cells are able to sense the mechanical properties of their surroundings. Cells make major decisions in response to this mechanosensation, including decisions regarding cell migration, proliferation, survival, and differentiation. The vast majority of these studies have focused on the cellular mechanoresponse to changing substrate stiffness (or elastic modulus) and have been conducted on purely elastic substrates. In contrast, most soft tissues in the human body exhibit viscoelastic behavior; that is, they generate responsive force proportional to both the magnitude and rate of strain. While several recent studies have demonstrated that viscous effects of an underlying substrate affect cellular mechanoresponse, there is not a straightforward experimental method to probe this, particularly for investigators with little background in biomaterial fabrication. In the current work, we demonstrate that polymers comprised of differing polydimethylsiloxane (PDMS) formulations can be generated that allow for control over both the strain-dependent storage modulus and the strain rate-dependent loss modulus. These substrates requires no background in biomaterial fabrication to fabricate, are shelf-stable, and exhibit repeatable mechanical properties. Here we demonstrate that these substrates are biocompatible and exhibit similar protein adsorption characteristics regardless of mechanical properties. Finally, we develop a set of empirical equations that predicts the storage and loss modulus for a given blend of PDMS formulations, allowing users to tailor substrate mechanical properties to their specific needs.

| S-EPMC9043277 | biostudies-literature

Revealing region-specific biofilm viscoelastic properties by means of a micro-rheological approach.

Project description:Particle-tracking microrheology is an in situ technique that allows quantification of biofilm material properties. It overcomes the limitations of alternative techniques such as bulk rheology or force spectroscopy by providing data on region specific material properties at any required biofilm location and can be combined with confocal microscopy and associated structural analysis. This article describes single particle tracking microrheology combined with confocal laser scanning microscopy to resolve the biofilm structure in 3 dimensions and calculate the creep compliances locally. Samples were analysed from Pseudomonas fluorescens biofilms that were cultivated over two timescales (24 h and 48 h) and alternate ionic conditions (with and without calcium chloride supplementation). The region-based creep compliance analysis showed that the creep compliance of biofilm void zones is the primary contributor to biofilm mechanical properties, contributing to the overall viscoelastic character.

| S-EPMC5460257 | biostudies-literature

Extensional rheological data from ex-situ measurements for predicting porous media behaviour of the viscoelastic EOR polymers.

Project description:In this article, extensional rheological data of various polymer solutions, to be used in Azad Trivedi viscoelastic model (AT-VEM) for predicting the viscoelastic behavior of synthetic polymer in porous media are provided. Extensional rheology measurements are performed for different polymer solutions using Capillary breakup extensional Rheometer (CaBER) to obtain the filament diameter with respect to time. Extensional rheological parameters, such as the extensional relaxation time, maximum elongational viscosity at the critical Deborah number and strain hardening index are determined from observed filament diameter with time-based on the Upper Convected Maxwell model, the finite extensible non-linear elastic model, and the power law model.

| S-EPMC6111059 | biostudies-literature

Rheological and Viscoelastic Properties of Chitosan Solutions Prepared with Different Chitosan or Acetic Acid Concentrations.

Project description:Chitosan (Ch) is a partially crystalline biopolymer, insoluble in pure water but soluble in acid solutions. It has attracted interest from researchers to prepare solutions using different acid types and concentrations. This research aims to study both the effect of chitosan (Ch) or acetic acid (Ac) concentrations, at different temperatures, on rheological and viscoelastic properties of Ch solutions. To study the effect of Ch, solutions were prepared with 0.5-2.5 g Ch/100 g of solution and Ac = 1%, whereas to study the effect of Ac, the solutions were prepared with 2.0 g of Ch/100 g of solution and Ac = 0.2-1.0%. Overall, all analyzed solutions behaved as pseudoplastic fluid. The Ch strongly affected rheological properties, the consistency index (K) increased and the index flow behavior (n) decreased as a function of Ch. The activation energy, defined as the energy required for the molecule of a fluid to move freely, was low for Ch = 0.5%. The effect of Ac was less evident. Both K and n varied according to a positive and negative, respectively, parabolic model as a function of Ac. Moreover, all solutions, irrespective of Ch and Ac, behaved as diluted solutions, with G" > G'. The relaxation exponent (n") was always higher than 0.5, confirming that these systems behaved as a viscoelastic liquid. This n" increased with Ch, but it was insensitive to Ac, being slightly higher at 45 °C.

| S-EPMC9455163 | biostudies-literature

Single Microbubble Measurements of Lipid Monolayer Viscoelastic Properties for Small-Amplitude Oscillations.

Project description:Lipid monolayer rheology plays an important role in a variety of interfacial phenomena, the physics of biological membranes, and the dynamic response of acoustic bubbles and drops. We show here measurements of lipid monolayer elasticity and viscosity for very small strains at megahertz frequency. Individual plasmonic microbubbles of 2-6 μm radius were photothermally activated with a short laser pulse, and the subsequent nanometer-scale radial oscillations during ring-down were monitored by optical scatter. This method provided average dynamic response measurements of single microbubbles. Each microbubble was modeled as an underdamped linear oscillator to determine the damping ratio and eigenfrequency, and thus the lipid monolayer viscosity and elasticity. Our nonisothermal measurement technique revealed viscoelastic trends for different lipid shell compositions. We observed a significant increase in surface elasticity with the lipid acyl chain length for 16 to 20 carbons, and this effect was explained by an intermolecular forces model that accounts for the lipid composition, packing, and hydration. The surface viscosity was found to be equivalent for these lipid shells. We also observed an anomalous decrease in elasticity and an increase in viscosity when increasing the acyl chain length from 20 to 22 carbons. These results illustrate the use of a novel nondestructive optical technique to investigate lipid monolayer rheology in new regimes of frequency and strain, possibly elucidating the phase behavior, as well as how the dynamic response of a microbubble can be tuned by the lipid intermolecular forces.

| S-EPMC5824650 | biostudies-literature

Viscoelastic Properties of Polymeric Microneedles Determined by Micromanipulation Measurements and Mathematical Modelling.

Project description:Microneedles, including dissolvable ones made from biocompatible and biodegradable materials, have been widely studied and can potentially be used for transdermal drug delivery, disease diagnosis (sampling), skin care, etc. Characterizing their mechanical properties is essential, as being mechanically strong enough to pierce the skin barrier is one of the most fundamental and crucial requirements for them. The micromanipulation technique was based on compressing single microparticles between two flat surfaces to obtain force and displacement data simultaneously. Two mathematical models had already been developed to calculate the rupture stress and apparent Young's modulus, which can identify variations of these parameters in single microneedles within a microneedle patch. In this study, a new model has been developed to determine the viscoelasticity of single microneedles made of hyaluronic acid (HA) with a molecular weight of 300 kDa loaded with lidocaine by using the micromanipulation technique to gather experimental data. The modelling results from the micromanipulation measurements suggest that the microneedles were viscoelastic and their mechanical behaviour was strain-rate dependent, which implies that the penetration efficiency of viscoelastic microneedles can be improved by increasing their piercing speed into the skin.

| S-EPMC10003889 | biostudies-literature

Fractional Moore-Gibson-Thompson heat transfer model with nonlocal and nonsingular kernels of a rotating viscoelastic annular cylinder with changeable thermal properties.

Project description:Long hollow cylinders are commonly utilized in various technological applications, including liquid and gas transmission. As a result, its value is growing, becoming increasingly important to many research efforts. Compared with thermal isotropic homogeneous cylinders, thermo-viscoelastic orthotropic cylinders have less relevant data. In this paper, a thermoelastic fractional heat conduction model was developed based on the Moore-Gibson-Thompson equation to examine the axial symmetry problem of a viscoelastic orthotropic hollow cylinder. Atangana and Baleanu derivative operators with nonsingular and nonlocal kernels were used in constructing the fractional model. The thermal properties of the cylinder materials are assumed to be temperature-dependent. The Laplace transform is applied to solve the system of governing equations. The numerical calculations for temperature, displacement, and stress components are performed by the effect of fractional order, rotation, and changing thermal properties of the cylinder. The results showed that due to the presence of fractional derivatives, some properties of the physical fields of the medium change according to the value of the fractional order.

| S-EPMC9212188 | biostudies-literature

Generalized Fractional Derivative Anisotropic Viscoelastic Characterization.

Project description:Isotropic linear and nonlinear fractional derivative constitutive relations are formulated and examined in terms of many parameter generalized Kelvin models and are analytically extended to cover general anisotropic homogeneous or non-homogeneous as well as functionally graded viscoelastic material behavior. Equivalent integral constitutive relations, which are computationally more powerful, are derived from fractional differential ones and the associated anisotropic temperature-moisture-degree-of-cure shift functions and reduced times are established. Approximate Fourier transform inversions for fractional derivative relations are formulated and their accuracy is evaluated. The efficacy of integer and fractional derivative constitutive relations is compared and the preferential use of either characterization in analyzing isotropic and anisotropic real materials must be examined on a case-by-case basis. Approximate protocols for curve fitting analytical fractional derivative results to experimental data are formulated and evaluated.

| S-EPMC5448942 | biostudies-other

Speckle rheological spectroscopy reveals wideband viscoelastic spectra of biological tissues.

Project description:Mechanical transformation of tissue is not merely a symptom but a decisive driver in pathological processes. Comprising intricate network of cells, fibrillar proteins, and interstitial fluid, tissues exhibit distinct solid-(elastic) and liquid-like (viscous) behaviours that span a wide band of frequencies. Yet, characterization of wideband viscoelastic behaviour in whole tissue has not been investigated, leaving a vast knowledge gap in the higher frequency range that is linked to fundamental intracellular processes and microstructural dynamics. Here, we present wideband Speckle rHEologicAl spectRoScopy (SHEARS) to address this need. We demonstrate, for the first time, analysis of frequency-dependent elastic and viscous moduli up to the sub-MHz regime in biomimetic scaffolds and tissue specimens of blood clots, breast tumours, and bone. By capturing previously inaccessible viscoelastic behaviour across the wide frequency spectrum, our approach provides distinct and comprehensive mechanical signatures of tissues that may provide new mechanobiological insights and inform novel disease prognostication.

| S-EPMC10274797 | biostudies-literature

Linear viscoelastic properties of the vertex model for epithelial tissues.

Project description:Epithelial tissues act as barriers and, therefore, must repair themselves, respond to environmental changes and grow without compromising their integrity. Consequently, they exhibit complex viscoelastic rheological behavior where constituent cells actively tune their mechanical properties to change the overall response of the tissue, e.g., from solid-like to fluid-like. Mesoscopic mechanical properties of epithelia are commonly modeled with the vertex model. While previous studies have predominantly focused on the rheological properties of the vertex model at long time scales, we systematically studied the full dynamic range by applying small oscillatory shear and bulk deformations in both solid-like and fluid-like phases for regular hexagonal and disordered cell configurations. We found that the shear and bulk responses in the fluid and solid phases can be described by standard spring-dashpot viscoelastic models. Furthermore, the solid-fluid transition can be tuned by applying pre-deformation to the system. Our study provides insights into the mechanisms by which epithelia can regulate their rich rheological behavior.

| S-EPMC9159552 | biostudies-literature

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data