Synchronous and metachronous bilateral breast cancer among women with a history of lobular carcinoma in situ.

ABSTRACT:

Purpose

Lobular carcinoma in situ (LCIS) confers increased cancer risk in either breast, but it remains unclear if this population is at increased risk for bilateral breast cancer (BC) development. Here we report bilateral BC incidence among women with a history of LCIS.

Methods

Women with classic-type LCIS diagnosed from 1980 to 2017 who developed unilateral BC (UBC) or bilateral BC were identified. Bilateral BC was categorized as synchronous (bilateral BC diagnosed < 6 months apart; SBBC) or metachronous (bilateral BC diagnosed ≥ 6 months apart; MBBC). Five-year incidence rates of bilateral BC among this population were evaluated. Comparisons were made to identify factors associated with bilateral BC.

Results

At 7 years' median follow-up, 249/1651 (15%) women with L

SUBMITTER: Mallory MA 

PROVIDER: S-EPMC11325477 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature