The clinical impacts of lung microbiome in bronchiectasis with fixed airflow obstruction: a prospective cohort study.

ABSTRACT:

Background

Airflow obstruction is a hallmark of disease severity and prognosis in bronchiectasis. The relationship between lung microbiota, airway inflammation, and outcomes in bronchiectasis with fixed airflow obstruction (FAO) remains unclear. This study explores these interactions in bronchiectasis patients, with and without FAO, and compares them to those diagnosed with chronic obstructive pulmonary disease (COPD).

Methods

This prospective observational study in Taiwan enrolled patients with either bronchiectasis or COPD. To analyze the lung microbiome and assess inflammatory markers, bronchoalveolar lavage (BAL) samples were collected for 16S rRNA gene sequencing. The study cohort comprised 181 patients: 86 with COPD, 46 with bronchiectasis, and 49 with bronchiectasis a

SUBMITTER: Chen YF 

PROVIDER: S-EPMC11325704 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature