Lipid-driven interleaflet coupling of plasma membrane order regulates FcεRI signaling in mast cells.

ABSTRACT: Interleaflet coupling-the influence of one leaflet on the properties of the opposing leaflet-is a fundamental plasma membrane organizational principle. This coupling is proposed to participate in maintaining steady-state biophysical properties of the plasma membrane, which in turn regulates some transmembrane signaling processes. A prominent example is antigen (Ag) stimulation of signaling by clustering transmembrane receptors for immunoglobulin E (IgE), FcεRI. This transmembrane signaling depends on the stabilization of ordered regions in the inner leaflet for sorting of intracellular signaling components. The resting inner leaflet has a lipid composition that is generally less ordered than the outer leaflet and that does not spontaneously phase separate in model membranes. We propose tha

SUBMITTER: Yang GS 

PROVIDER: S-EPMC11331041 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature