Immune cell populations in the tumour environment following calcium electropora-tion for cutaneous metastasis: a histopathological study.

ABSTRACT:

Background and purpose

Calcium electroporation (CaEP) involves injecting calcium into tumour tissues and using electrical pulses to create membrane pores that induce cell death. This study assesses resultant immune responses and histopathological changes in patients with cutaneous metastases.

Patients/materials and methods

The aimed cohort comprised 24 patients with metastases exceeding 5 mm. Tumours were treated once with CaEP (day 0) or twice (day 28). Biopsies were performed on days 0 and 2, with additional samples on days 7, 28, 30, 35, 60, and 90 if multiple tumours were treated. The primary endpoint was the change in tumour-infiltrating lymphocytes (TILs) two days post-treatment, with secondary endpoints evaluating local and systemic immune responses via histopathologi

SUBMITTER: Vissing M 

PROVIDER: S-EPMC11332521 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature