Analysis of IDH and EGFR as biomarkers in glioblastoma multiforme: A case-control study.

ABSTRACT:

Background

Glioblastoma multiforme (GBM) is a very aggressive primary central nervous system (CNS) tumor with limited therapeutic options and poor prognosis. This study aimed to analyze the association between single nucleotide polymorphisms (SNPs), including IDH1 rs121913500C > T, IDH2 rs11540478G > A, and EGFR rs1468727C > T, and their association on the risk and overall survival of GBM patients in Jordan.

Methods

Using a case-control study design involving 63 GBM patients and 226 healthy controls was conducted at King Abdullah University Hospital in Jordan. DNA extraction was performed using formalin-fixed and paraffin-embedded tissue for GBM samples and blood samples for controls. SNPs analysis was performed using the Sequenom iPLEX assay sequencing technique. Survival o

SUBMITTER: Al-Khatib SM 

PROVIDER: S-EPMC11333891 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature