Construction and validation of a ubiquitination-related prognostic risk score signature in breast cancer.

ABSTRACT:

Background

Breast cancer (BC) is a highly common form of cancer that occurs in many parts of the world. However, early -stage BC is curable. Many patients with BC have poor prognostic outcomes owing to ineffective diagnostic and therapeutic tools. The ubiquitination system and associated proteins were found influencing the outcome of individuals with cancer. Therefore, developing a biomarker associated with ubiquitination genes to forecast BC patient outcomes is a feasible strategy.

Objective

The primary goal of this work was to develop a novel risk score signature capable of accurately estimate the future outcome of patients with BC by targeting ubiquitinated genes.

Methods

Univariate Cox regression analysis was conducted utilizing the E1, E2, and E3 ubiquitination-r

SUBMITTER: Feng K 

PROVIDER: S-EPMC11336713 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature