Dysregulated T-cell homeostasis and decreased CD30⁺ Treg proliferating in aplastic anemia.

ABSTRACT: Aplastic anemia (AA) is an autoimmune hematopoietic disease mediated by autoreactive T cells leading to bone marrow failure. However, the precise role of autoreactive T cells in the development of AA is not fully understood, hindering the advancement of therapeutic and diagnostic strategies. In this study, we conducted a single-cell transcriptome analysis of CD8⁺ T cells, conventional CD4⁺ T (CD4⁺ Tconv) cells, and Treg cells, to elucidate the potential disruption of T cell homeostasis in patients with AA. We identified changes in CD4⁺ Tconv cells, including loss of homeostasis in naïve and memory cells and increased differentiation potential in T helper type 1 (TH1), T helper type 2 (TH2), and T helper type 17 (TH17) cells. Additionally, we iden

SUBMITTER: Sun N 

PROVIDER: S-EPMC11337026 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature