Selective nanosecond laser removal of retinal pigment epithelium for cell therapy.

ABSTRACT: Retinal pigment epithelial (RPE) cells play a crucial role in the health of the retina, and their dysfunction is associated with various ocular diseases. The transplantation of RPE cells has been proposed as a potential treatment for numerous degenerative diseases, including geographic atrophy from macular degeneration. However, current models to induce RPE damage in animal models prior to transplantation involve mechanical scraping, chemical administration, or laser photocoagulation techniques, which can damage the overlying neurosensory retina. This study aims to investigate the feasibility and efficacy of nanosecond duration laser treatment to safely remove large areas of RPE cells without causing damage to the adjacent tissue or affecting the retinal architecture. Twelve pigmented rabb

SUBMITTER: Nguyen VP 

PROVIDER: S-EPMC11339075 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature