APOL1 polymorphisms are not influencing acute coronary syndrome risk in Czech males.

ABSTRACT:

Background

The highest mortality and morbidity worldwide is associated with atherosclerotic cardiovascular disease (ASCVD), which has in background both environmental and genetic risk factors. Apolipoprotein L1 (APOL1) variability influences the risk of ASCVD in Africans, but little is known about the APOL1 and ASCVD in other ethnic groups.

Methods

To investigate the role of APOL1 and ASCVD, we have genotyped four (rs13056427, rs136147, rs10854688 and rs9610473) APOL1 polymorphisms in a group of 1541 male patients with acute coronary syndrome (ACS) and 1338 male controls.

Results

Individual APOL1 polymorphisms were not associated with traditional CVD risk factors such as smoking, hypertension or diabetes prevalence, with BMI values or plasma lipid levels. Neither indi

SUBMITTER: Hubacek JA 

PROVIDER: S-EPMC11339648 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature