Blocking IL-33 decelerates cartilage degeneration in knee osteoarthritis through mice model.

ABSTRACT:

Introduction

Osteoarthritis (OA) is a chronic inflammatory disease where pro-inflammatory cytokines, damage-associated molecular patterns and macrophages play a crucial role. However, the interaction of these mediators, the exact cause, and the treatment of knee osteoarthritis (KOA) are still unclear. Moreover, the interaction of interleukin (IL)-33, platelet-derived growth factor-BB (PDGF-BB), and matrix metalloproteinase-9 (MMP-9) with other factors in the pathogenesis of KOA has not been elaborately explored.

Method

Therefore, in this study, we analyzed the expression of IL-33, PDGF-BB, and MMP-9 in the knee cartilage tissue of model mice, murine KOA was induced by using the destabilization of the medial meniscus (DMM) model.

Results

Compared with the sham operatio

SUBMITTER: Wu F 

PROVIDER: S-EPMC11340949 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature