The structural characterization and UV-protective properties of an exopolysaccharide from a Paenibacillus isolate.

ABSTRACT:

Introduction

Overexposure to ultraviolet (UV) light is known to cause damage to the skin, leading to sunburn and photo-aging. Chemical sunscreen products may give rise to health risks including phototoxicity, photosensitivity, and photosensitivity. Natural polysaccharides have attracted considerable interests due to diverse biological activities.

Methods

A novel polysaccharide isolated was purified and structurally characterized using chemical methods followed by HPLC, GLC-MS, as well as 1D and 2D NMR spectroscopy. The photoprotective effect of the EPS on UVB-induced damage was assessed in vitro using cultured keratinocytes and in vivo using C57BL/6 mouse models.

Results

The average molecular weight of the EPS was 5.48 × 10⁶ Da, composed of gl

SUBMITTER: Xu X 

PROVIDER: S-EPMC11341463 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature