Arc and BDNF mediated effects of hippocampal astrocytic glutamate uptake blockade on spatial memory stages.

ABSTRACT: Glutamate is involved in fundamental functions, including neuronal plasticity and memory. Astrocytes are integral elements involved in synaptic function, and the GLT-1 transporter possesses a critical role in glutamate uptake. Here, we study the role of GLT-1, specifically located in astrocytes, in the consolidation, expression, reconsolidation and persistence of spatial object recognition memory in rats. Administration of dihydrokainic acid (DHK), a selective GLT-1 inhibitor, into the dorsal hippocampus around a weak training which only induces short-term memory, promotes long-term memory formation. This promotion is prevented by hippocampal administration of protein-synthesis translation inhibitor, blockade of Activity-regulated cytoskeleton-associated protein (Arc) translation or Brain-

SUBMITTER: Riboldi JG 

PROVIDER: S-EPMC11341830 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature