Robotic right ventricle is a biohybrid platform that simulates right ventricular function in (patho)physiological conditions and intervention.

ABSTRACT: The increasing recognition of the right ventricle (RV) necessitates the development of RV-focused interventions, devices and testbeds. In this study, we developed a soft robotic model of the right heart that accurately mimics RV biomechanics and hemodynamics, including free wall, septal and valve motion. This model uses a biohybrid approach, combining a chemically treated endocardial scaffold with a soft robotic synthetic myocardium. When connected to a circulatory flow loop, the robotic right ventricle (RRV) replicates real-time hemodynamic changes in healthy and pathological conditions, including volume overload, RV systolic failure and pressure overload. The RRV also mimics clinical markers of RV dysfunction and is validated using an in vivo porcine model. Additionally, the RRV recreate

SUBMITTER: Singh M 

PROVIDER: S-EPMC11343235 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature