Alterations in the gut microbiota community are associated with childhood obesity and precocious puberty.

ABSTRACT:

Objective

To explore the distribution and differences in the intestinal microbiota in girls with obesity-related precocious puberty and the relationship between intestinal microbiota and obesity-related precocious puberty.

Methods

16 S rRNA gene amplicons from fecal samples from girls with precocious puberty and obesity-complicated precocious puberty and healthy children were sequenced to define microbial taxa.

Results

The α- and β-diversity indices of the microbiome significantly differed among the three groups. At the phylum level, the proportions of Firmicutes, Actinobacteriota, Bacteroidota, Bacteria, Campylobacterota, and Acidobacteriota were different. At the genus level, there were differences in Bifidobacterium, Bacteroides, Anaerostipes, Fusicatenibacter, Kle

SUBMITTER: Wang L 

PROVIDER: S-EPMC11344344 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature