Functional connexion of bacterioferritin in antibiotic production and morphological differentiation in Streptomyces coelicolor.

ABSTRACT:

Background

Several two-component systems of Streptomyces coelicolor, a model organism used for studying antibiotic production in Streptomyces, affect the expression of the bfr (SCO2113) gene that encodes a bacterioferritin, a protein involved in iron storage. In this work, we have studied the effect of the deletion mutant ∆bfr in S. coelicolor.

Results

The ∆bfr mutant exhibits a delay in morphological differentiation and produces a lesser amount of the two pigmented antibiotics (actinorhodin and undecylprodigiosin) compared to the wild type on complex media. The effect of iron in minimal medium was tested in the wild type and ∆bfr mutant. Consequently, we also observed different levels of production of the two pigmented antibiotics between the two strains, depending on the i

SUBMITTER: Garcia-Martin J 

PROVIDER: S-EPMC11344345 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature