Investigating CR1 as an indicated Gene for mild cognitive impairment in type 2 diabetes mellitus.

ABSTRACT:

Objective

Type 2 diabetes mellitus (T2DM) has beenis known as an important risk factor for cognitive impairment. Meanwhile, the liver plays a central role in the development of T2DM and insulin resistance. The present study attempted to identify and validate marker genes for mild cognitive impairment (MCI) in patients with T2DM.

Methods

In this study, insulin resistance-related differentially expressed genes were identified from the liver tissues of individuals with T2DM and those with normal glucose tolerance using the Gene Expression Omnibus database and MCI-associated genes were identified using the GeneCards database. Next, enrichment analysis was performed with overlapping T2DM and MCI genes, followed by the identification of specific genes using the LASSO logistic regr

SUBMITTER: Zhou X 

PROVIDER: S-EPMC11344402 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature