Association between Helicobacter pylori and its eradication and the development of cancer.

ABSTRACT:

Background

Helicobacter pylori (H. pylori) is a gram-negative gastrointestinal pathogen that colonises the human stomach and is considered a major risk factor for gastric cancer and mucosa-associated lymphoid tissue lymphoma. Furthermore, H. pylori is a potential trigger of a wide spectrum of extragastric cancer entities, extraintestinal chronic inflammatory processes and autoimmune diseases. In the present study, we evaluated the association between H. pylori infection and its eradication with the development of subsequent gastrointestinal and non-gastrointestinal cancer.

Methods

We identified 25 317 individuals with and 25 317 matched individuals without a diagnosis of H. pylori from the Disease Analyzer database (IQVIA). A subsequent can

SUBMITTER: Loosen SH 

PROVIDER: S-EPMC11344509 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature