Phase 2 Re-Entry Without I_to: Role of Sodium Channel Kinetics in Brugada Syndrome Arrhythmias.

ABSTRACT:

Background

In Brugada syndrome (BrS), phase 2 re-excitation/re-entry (P2R) induced by the transient outward potassium current (I_to) is a proposed arrhythmia mechanism; yet, the most common genetic defects are loss-of-function sodium channel mutations.

Objectives

The authors used computer simulations to investigate how sodium channel dysfunction affects P2R-mediated arrhythmogenesis in the presence and absence of I_to.

Methods

Computer simulations were carried out in 1-dimensional cables and 2-dimensional tissue using guinea pig and human ventricular action potential models.

Results

In the presence of I_to sufficient to generate robust P2R, reducing sodium current (I_Na) peak amplitude alone only slightly potentiated P2R.

SUBMITTER: Zhang Z 

PROVIDER: S-EPMC11348283 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature