Glial fibrillary acidic protein and neurofilament light chain as biomarkers in pediatric multiple sclerosis.

ABSTRACT:

Background

Serum neurofilament light chain (sNfL) is a marker of neuroaxonal injury, and serum glial fibrillary acidic protein (sGFAP) reflects reactive astrogliosis. In adult multiple sclerosis (MS), sNfL correlates with relapsing disease activity while sGFAP correlates with progressive disease.

Objectives

We evaluate sNfL and sGFAP as biomarkers in pediatric-onset MS (POMS) compared to pediatric healthy controls (PHC), and correlations with the disease course.

Methods

In this single-center observational cross-sectional study, we extracted data from a longitudinal database and measured NfL and GFAP from bio-banked serum using single-molecule array technology.

Results

The analysis included 61 POMS patients and 45 PHC. Controlling for age and BMI, sNfL was 414%

SUBMITTER: Saucier L 

PROVIDER: S-EPMC11348348 | biostudies-literature | 2024 Jul-Sep

REPOSITORIES: biostudies-literature