Efficacy and safety of etrolizumab in the treatment of inflammatory bowel disease: a meta-analysis.

ABSTRACT:

Background

To explore the efficacy and safety of etrolizumab in treating inflammatory bowel disease (IBD) through meta-analysis.

Method

A comprehensive exploration encompassed randomized controlled trials examining the efficacy of etrolizumab in treating IBD across PubMed, Embase, Cochrane library, and Web of Science, with a search deadline of 1 December 2023. Quality assessment leaned on the Cochrane manual's risk-of-bias evaluation, while Stata 15 undertook the data analysis.

Result

Five randomized controlled studies involving 1682 individuals were finally included, Meta-analysis results suggested that compared with placebo, etrolizumab could improve clinical response (RR = 1.26, 95% CI [1.04-1.51]), clinical remission (RR = 1.26, 95% CI [1.04-1.51]) in IBD patients

SUBMITTER: Dai YG 

PROVIDER: S-EPMC11348897 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature