Dataset Information

Efficacy and safety of etrolizumab in the treatment of inflammatory bowel disease: a meta-analysis.

ABSTRACT:

Background

To explore the efficacy and safety of etrolizumab in treating inflammatory bowel disease (IBD) through meta-analysis.

Method

A comprehensive exploration encompassed randomized controlled trials examining the efficacy of etrolizumab in treating IBD across PubMed, Embase, Cochrane library, and Web of Science, with a search deadline of 1 December 2023. Quality assessment leaned on the Cochrane manual's risk-of-bias evaluation, while Stata 15 undertook the data analysis.

Result

Five randomized controlled studies involving 1682 individuals were finally included, Meta-analysis results suggested that compared with placebo, etrolizumab could improve clinical response (RR = 1.26, 95% CI [1.04-1.51]), clinical remission (RR = 1.26, 95% CI [1.04-1.51]) in IBD patients. Endoscopic alleviate (RR = 2.10, 95% CI [1.56-2.82]), endoscopic improvement (RR = 2.10, 95% CI [1.56-2.82]), endoscopic remission (RR = 2.10, 95% CI [1.56-2.82]), Endoscopic improvement (RR = 1.56, 95% CI [1.30-1.89]), histological remission (RR = 1.62, 95% CI [1.26-2.08]), and did not increase any adverse events (RR = 0.95, 95% CI [0.90-1.01]) and serious adverse events (RR = 0.94, 95% CI [0.68-1.31]).

Conclusion

According to our current study, etrolizumab is a promising drug in IBD.

SUBMITTER: Dai YG

PROVIDER: S-EPMC11348897 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Efficacy and safety of etrolizumab in the treatment of inflammatory bowel disease: a meta-analysis.

Dai Yong Gang YG Sun Dajuan D Liu Jiahui J Wei Xiunan X Chi Lili L Wang Hongya H

PeerJ 20240823

<h4>Background</h4>To explore the efficacy and safety of etrolizumab in treating inflammatory bowel disease (IBD) through meta-analysis.<h4>Method</h4>A comprehensive exploration encompassed randomized controlled trials examining the efficacy of etrolizumab in treating IBD across PubMed, Embase, Cochrane library, and Web of Science, with a search deadline of 1 December 2023. Quality assessment leaned on the Cochrane manual's risk-of-bias evaluation, while Stata 15 undertook the data analysis.<h4 ...[more]

PMID: 39193512

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Dataset Information

Efficacy and safety of etrolizumab in the treatment of inflammatory bowel disease: a meta-analysis.

Background

Method

Result

Conclusion

Publications

Efficacy and safety of etrolizumab in the treatment of inflammatory bowel disease: a meta-analysis.

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