Time-encoded ASL reveals lower cerebral blood flow in the early AD continuum.

ABSTRACT:

Introduction

Cerebral blood flow (CBF) is reduced in cognitively impaired (CI) Alzheimer's disease (AD) patients. We checked the sensitivity of time-encoded arterial spin labeling (te-ASL) in measuring CBF alterations in individuals with positive AD biomarkers and associations with relevant biomarkers in cognitively unimpaired (CU) individuals.

Methods

We compared te-ASL with single-postlabel delay (PLD) ASL in measuring CBF in 59 adults across the AD continuum, classified as CU amyloid beta (Aβ) negative (-), CU Aβ positive (+), and CI Aβ+. We sought associations of CBF with biomarkers of AD, cerebrovascular disease, synaptic dysfunction, neurodegeneration, and cognition in CU participants.

Results

te-ASL was more sensitive at detecting CBF reduction in the CU Aβ+ an

SUBMITTER: Falcon C 

PROVIDER: S-EPMC11350027 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature