Drug Repurposing for COVID-19 by Constructing a Comorbidity Network with Central Nervous System Disorders.

ABSTRACT: In the post-COVID-19 era, treatment options for potential SARS-CoV-2 outbreaks remain limited. An increased incidence of central nervous system (CNS) disorders has been observed in long-term COVID-19 patients. Understanding the shared molecular mechanisms between these conditions may provide new insights for developing effective therapies. This study developed an integrative drug-repurposing framework for COVID-19, leveraging comorbidity data with CNS disorders, network-based modular analysis, and dynamic perturbation analysis to identify potential drug targets and candidates against SARS-CoV-2. We constructed a comorbidity network based on the literature and data collection, including COVID-19-related proteins and genes associated with Alzheimer's disease, Parkinson's disease, multiple sc

SUBMITTER: Qian J 

PROVIDER: S-EPMC11354300 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature