The Discovery of a Specific CKIP-1 Ligand for the Potential Treatment of Disuse Osteoporosis.
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SUBMITTER: Wei Y
PROVIDER: S-EPMC11354310 | biostudies-literature | 2024 Aug
REPOSITORIES: biostudies-literature
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The Discovery of a Specific CKIP-1 Ligand for the Potential Treatment of Disuse Osteoporosis.
Wei Yange Y Wu Bo B Liu Mingqiu M Cui Chun-Ping CP
International journal of molecular sciences 20240815 16
Bone homeostasis relies on the delicate balance between osteoblast-mediated bone formation and osteoclast-mediated bone resorption. The casein kinase 2 interacting protein-1 (CKIP-1), a specific CK2α subunit-interacting protein, has been documented as one of the crucial negative regulators of bone formation. CKIP-1 siRNA therapy has constraints that limit its use in clinical applications. Therefore, it is necessary to explore effective targeting strategies for CKIP-1. In this study, we observed ...[more]
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