High expression of SIGLEC7 may promote M2-type macrophage polarization leading to adverse prognosis in glioma patients.

ABSTRACT:

Introduction

Gliomas are the most common primary intracranial tumors, known for their high invasiveness and destructiveness. Sialic acid-binding immunoglobulin-like lectin 7 (SIGLEC7) is present in various immune cells, especially macrophages, and significantly affects immune homeostasis and cancer cell response. However, research on the role and prognostic impact of SIGLEC7 in glioma patients is currently limited.

Methods

We utilized transcriptomic data from 702 glioma patients in The Cancer Genome Atlas (TCGA) and 693 glioma patients in the Chinese Glioma Genome Atlas (CGGA), along with clinical samples we collected, to comprehensively investigate the impact of SIGLEC7 on glioma expression patterns, biological functions, and prognostic value. We focused on its role in glio

SUBMITTER: An W 

PROVIDER: S-EPMC11357930 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature