The relationship between hippocampal changes in healthy aging and Alzheimer's disease: a systematic literature review.

ABSTRACT:

Introduction

Neurobiological changes in the hippocampus are a common consequence of aging. However, there are differences in the rate of decline and overall volume loss in people with no cognitive impairment compared to those with mild cognitive impairment (MCI) and Alzheimer's disease (AD). This systematic literature review was conducted to determine the relationship between hippocampal atrophy and changes in hippocampal volume in the non-cognitively impaired brain and those with MCI or AD.

Methods

This systematic review was guided by the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) methodology. The PubMed database was searched up to September 15, 2022, for longitudinal magnetic resonance imaging studies reporting hippocampal atrophy or volume

SUBMITTER: Woodward M 

PROVIDER: S-EPMC11357962 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature