TWAS-GKF: a novel method for causal gene identification in transcriptome-wide association studies with knockoff inference.

ABSTRACT:

Motivation

Transcriptome-wide association study (TWAS) aims to identify trait-associated genes regulated by significant variants to explore the underlying biological mechanisms at a tissue-specific level. Despite the advancement of current TWAS methods to cover diverse traits, traditional approaches still face two main challenges: (i) the lack of methods that can guarantee finite-sample false discovery rate (FDR) control in identifying trait-associated genes; and (ii) the requirement for individual-level data, which is often inaccessible.

Results

To address this challenge, we propose a powerful knockoff inference method termed TWAS-GKF to identify candidate trait-associated genes with a guaranteed finite-sample FDR control. TWAS-GKF introduces the main idea of Ghostknockoff

SUBMITTER: Wang A 

PROVIDER: S-EPMC11361808 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature