Influenza vaccination stimulates maturation of the human T follicular helper cell response.

ABSTRACT: The differentiation and specificity of human CD4⁺ T follicular helper cells (T_FH cells) after influenza vaccination have been poorly defined. Here we profiled blood and draining lymph node (LN) samples from human volunteers for over 2 years after two influenza vaccines were administered 1 year apart to define the evolution of the CD4⁺ T_FH cell response. The first vaccination induced an increase in the frequency of circulating T_FH (cT_FH) and LN T_FH cells at week 1 postvaccination. This increase was transient for cT_FH cells, whereas the LN T_FH cells further expanded during week 2 and remained elevated in frequency for at least 3 months. We observed several distinct subsets of T_FH cel

SUBMITTER: Schattgen SA 

PROVIDER: S-EPMC11362011 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature