Hepatocyte-derived tissue extracellular vesicles safeguard liver regeneration and support regenerative therapy.

ABSTRACT: Tissue-derived extracellular vesicles (EVs) are emerging as pivotal players to maintain organ homeostasis, which show promise as a next-generation candidate for medical use with extensive source. However, the detailed function and therapeutic potential of tissue EVs remain insufficiently studied. Here, through bulk and single-cell RNA sequencing analyses combined with ultrastructural tissue examinations, we first reveal that in situ liver tissue EVs (LT-EVs) contribute to the intricate liver regenerative process after partial hepatectomy (PHx), and that hepatocytes are the primary source of tissue EVs in the regenerating liver. Nanoscale and proteomic profiling further identify that the hepatocyte-specific tissue EVs (Hep-EVs) are strengthened to release with carrying proliferative message

SUBMITTER: Ying SQ 

PROVIDER: S-EPMC11363633 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature