MiR-106a targets ATG7 to inhibit autophagy and angiogenesis after myocardial infarction.

ABSTRACT:

Background

Myocardial infarction (MI) is an acute condition in which the heart muscle dies due to the lack of blood supply. Previous research has suggested that autophagy and angiogenesis play vital roles in the prevention of heart failure after MI, and miR-106a is considered to be an important regulatory factor in MI. But the specific mechanism remains unknown. In this study, using cultured venous endothelial cells and a rat model of MI, we aimed to identify the potential target genes of miR-106a and discover the mechanisms of inhibiting autophagy and angiogenesis.

Methods

We first explored the biological functions of miR-106a on autophagy and angiogenesis on endothelial cells. Then we identified ATG7, which was the downstream target gene of miR-106a. The expression of miR-

SUBMITTER: Bai G 

PROVIDER: S-EPMC11369033 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature