Astrocytic 5-HT_1A receptor mediates age-dependent hippocampal LTD and fear memory extinction in male mice.

ABSTRACT: NMDA receptor-dependent long-term depression (LTD) in the hippocampus is a well-known form of synaptic plasticity that has been linked to different cognitive functions. Although the underlying mechanisms remain unclear, this form of LTD cannot be induced by low-frequency stimulation (LFS) in adult mice. In this study, we found that LFS-induced LTD was not easily induced in adult animals and was age dependent. Interestingly, the level of the 5-HT_1A receptor was correspondingly increased and exhibited an inverse correlation with the magnitude of LFS-LTD during development. Knockout or pharmacological inhibition of the 5-HT_1A receptor reversed impaired LFS-LTD in adult mice (P60), while activation or inhibition of this receptor disturbed or enhanced LFS-LTD in adolescent

SUBMITTER: Wu QY 

PROVIDER: S-EPMC11371825 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature