Whole exome sequencing identifies genetic markers of enterovirus susceptibility in East Asians.

ABSTRACT:

Introduction

Following acute enterovirus (EV) infection, outcomes vary based on factors like the immune response, viral cell entry receptor expression levels, tissue tropism, and genetic factors of both the host and virus. While most individuals exhibit mild, self-limited symptoms, others may suffer severe complications or prolonged infections that can lead to autoimmune disorders.

Methods

To elucidate host responses to EV infection, we performed whole exome sequencing on blood samples from both infected and uninfected individuals. Our initial focus was on genes encoding EV entry receptors-PSGL-1, SCARB2, and ANAXA2 for EV-A71, and CD155 for poliovirus-and on host genes ACBD3 and PI4KΒ, crucial for EV replication.

Results

Although no specific genetic var

SUBMITTER: Sung CC 

PROVIDER: S-EPMC11372244 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature