Serum PCSK9 is a novel serological biomarker for the diagnosis and prognosis of pancreatic cancer.

ABSTRACT:

Background

Although CA19-9 is an essential blood biomarker of pancreatic cancer (PC), its sensitivity and specificity are limited for early detection.

Methods

We analyzed the serum proprotein convertase subtilisin/kexin type 9 (sPCSK9) in PC patients, benign disease groups (BDG), and healthy controls (HC) by ELISA.

Results

Consistently, sPCSK9 was considerably lower in PC patients than in HC (Z = -2.546, P < 0.05), and sPCSK9 in PC patients was statistically significantly higher than in BDG (Z = -5.457, P < 0.001). sPCSK9 was linked to the invasion of lymph nodes (χ² = 6.846, P < 0.01). According to ROC curves, combining sPCSK9 with CA19-9 could potentially enhance the diagnostic capability of CA19-9 in early-stage PC patients. Furtherm

SUBMITTER: Xu Y 

PROVIDER: S-EPMC11397121 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature