Smallest Clinically Meaningful Improvement in Amputation-Related Pain and Brief Pain Inventory Scores as Defined by Patient Reports of Global Improvement After Cryoneurolysis: a Retrospective Analysis of a Randomized, Controlled Clinical Trial.

ABSTRACT:

Background

The smallest meaningful improvement in pain scores (minimal clinically important difference [MCID]) after an analgesic intervention is essential information when both interpreting published data and designing a clinical trial. However, limited information is available for patients with chronic pain conditions, and what is published is derived from studies involving pharmacologic and psychological interventions. We here calculate these values based on data collected from 144 participants of a previously published multicenter clinical trial investigating the effects of a single treatment with percutaneous cryoneurolysis.

Methods

In the original trial, we enrolled patients with a lower-limb amputation and established phantom pain. Each received a single-injection fem

SUBMITTER: Ilfeld BM 

PROVIDER: S-EPMC11399314 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature