Integration of bile proteomics and metabolomics analyses reveals novel insights into different types of gallstones in a high-altitude area.

ABSTRACT:

Background

To explore the pathogenesis of different subtypes of gallstones in high-altitude populations from a molecular perspective.

Methods

We collected bile samples from 20 cholesterol gallstone disease (CGD) patients and 20 pigment gallstone disease (PGD) patients. Proteomics analysis was performed by LC/MS DIA, while metabolomics analysis was performed by UPLC- Q-TOF/MS.

Results

We identified 154 up-regulated and 196 down-regulated differentially expressed proteins, which were significantly enriched in neurodegenerative diseases, energy metabolism, amino acid metabolism etc. In metabolomics analysis, 20 up-regulated and 63 down-regulated differentially expressed metabolites were identified, and they were significantly enriched in vitamin B6 metabolism. Three path

SUBMITTER: Jing X 

PROVIDER: S-EPMC11440720 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature